I've used the rare book readers at the British Library, and liked them quite a lot. While they didn't include every feature one could imagine, they did have a very intuitive interface. (The readers actually in the British Library are better than the online version, because their screens are desk-sized.) UM has a rare book reader too:
Modeled on similar projects at The British Library and the National Library of Medicine, our “PictureIt” site puts some of the most beautiful and sought‐after items in our collections into the hands of readers worldwide – virtually.